The transition of novel and potentially promising medical therapies into their initial human clinical trials can engender conflicting pressures. On the one side, because Phase I trials raise greater ethical and human protection challenges than later stage clinical trials, there is a need to proceed cautiously. This is particularly the case for Phase I trials with a novel therapy being tested in humans for the first time, usually termed first-in-human (FIH) trials, especially if the FIH trial involves significant risks. On (...) the other side, scientists interested in having their research validated, corporations with a financial interest in the field, and potential patients and patient support groups desirous of having .. (shrink)

«Existe-t-il une argumentation juridique?», c’est la question à laquelle tente de répondre l’ouvrage de Stefan Goltzberg, intitulé explicitement L’argumentation juridique. Si l’auteur commence son ouvrage en posant directement la question, on en cherche aussitôt, par un réflexe de «juriste», la définition. Et il faut probablement lire l’intégralité de ce petit ouvrage pour voir se profiler une définition de l’argumentation juridique. Or, au cours de cette lecture Stefan Goltzberg nous montre en quoi chercher la définition, la poser, est déjà une marque (...) argumentative (p. 25) et certainement une marque de l’argumentation juridique. Or, Stefan Goltzberg n’est pas juriste de formation. Philosophe et linguiste, il est, notamment membre du Centre Perelman de philosophie du droit au sein duquel il a écrit une thèse de philosophie intitulé Théorie et histoire de la philosophie du droit, philosophie du droit de Chaïm Perelman, de Theodor Viehweg, de Roscoe Pound.Le droit est d’abord un objet d’ .. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Body and Soul in the Philosophy of Plotinus AUDREY N. M. RICH BEFORE THE TIME Of Aristotle, there had been no serious philosophical enquiry into the relation existing between the body and the soul. Admittedly, in those Dialogues of Plato in which the problem of Motion begins to assume importance, something approaching a scientific interest in the question starts to emerge. In the Phaedrus, for instance, the soul (...) is considered as the source of all bodily movement and change,1 and in the Timaeus, the interaction of body and soul is given some attention and a special bodily organ allotted to each phase of the tripartite soul (69c-71a). But it is fair to say that on the whole, Plato does not give the impression of being vitally concerned about the soul-body relation. In fact, in the Phaedo, he makes it abundantly clear that he views such an association as morally regrettable rather than scientifically interesting; at this stage of his thought, he prefers, like Socrates, to ignore such questions as those discussed by Empedocles and Alcmaeon, namely, "whether we think with the blood, or whether it is the brain that is the seat of sensation" (96b). Thus, to some extent Plato merits the censure of Aristotle who, in the De Anirna (I:1,407b15-18), ranks him among those who "associate the soul with and place it in the body without specifying why this is so and how the body is conditioned." In Aristotle's opinion, examination of the soul-body connection is essential: "for it is by this association that the one acts and the other is acted upon, that the one moves and the other is moved; and no such mutual relation is found in haphazard combinations" (407b 18-21). Now there is a strong likelihood that Aristotle's criticism of Plato on this point may have led Plotinus to take up the problem to some extent neglected by his master. He must have known the De Anima, probably through the commentaries of Alexander of Aphrodisias which, we know, were read in his school along with the writings of other Peripatetics like Aspasius and Adrastus2; and although he did not himself envisage the soul-body relation in Aristotelian terms, nevertheless his whole enquiry into the subject is deeply colored by the language and influence of the De Anirna. Of course, Plotinus is much too loyal a Platonist to remain untouched by the dualism of the t245c-e; cp. Laws X: 898c5. ~Porphyry, Life of Plotinus, c. 15. [q 2 HISTORY OF PHILOSOPHY Phaedo, and the undertone of suspicion and hostility toward the body which is lacking in the De Anima but present in much of Plato, runs right through the Enneads of Plotinus. In fact, almost the last words of his final treatise on psychology reveal that this uneasy attitude persists to the end: "Life in the body," he says, "is in itself evil.''~ Strictly speaking, however, the extreme dualism of a Dialogue like the Phaedo has no real place in Plotinus' system. In his view, both body and soul are alike descended from the primal Absolute or One; each represents a different stage in the evolution of plurality from unity; soul is an earlier stage, body, a later; and though soul does not require body in order to exist, nevertheless, without body, it could never come forth fTom the intelligible realm to display its powers in the visible universe (IV: 3.9). Thus, because body is, in a sense, necessary to soul, because, figuratively speaking, it is the only "place" appropriate for the soul's occupation (IV: 3.9), it is impossible to view the relation between body and soul as one of unmitigated hostility. For to some extent, body and soul imply each other. On the cosmic level indeed, they never exist apart. For though we may speak of the "ensoulment" (~Ft~c0oLg) of the cosmos, because the cosmos is, in fact, eternal and uncreated, there never was a time when its soul and its body were dissociated (IV : 3.9). In the case of the human soul and body, however, matters are rather different, since it is evident that the two were separate... (shrink)

We report on the small-scale (0.5 13 h - 1M, a large-scale bias of ~2.0 and a satellite fraction of 12 ± 2 per cent. Thus, these galaxies occupy haloes with average masses in between those of the higher redshift BOSS CMASS sample and the original SDSS I/II luminous red galaxy sample © 2012 The Authors Published by Oxford University Press on behalf of the Royal Astronomical Society © doi:10.1093/mnras/sts314.

La fouille du puits 883, menée par la mission française de Kition à Bamboula (2017-2018), a livré de nombreux restes fauniques au sein d’un comblement daté du ive siècle apr. J.‑C. Cet article présente les résultats d’une étude collaborative réalisée par des archéozoologues qui ont mis en évidence une grande diversité animale (bétail, carnivores, coquillages, oiseaux, rongeurs, reptiles, poissons). Ce matériel faunique offre l’opportunité d’aborder le paysage animalier d’un secteur de la ville antique dans sa multiplicité, avec des animaux liés (...) directement aux pratiques économiques et domestiques (élevage, consommation carnée, utilisation d’animaux auxiliaires) dont les déchets s’avèrent de différentes natures (alimentaires, équarrissage, cadavres animaux). D’autres espèces, plus discrètes, ont su profiter des déchets et denrées produites par les habitants de ce quartier, témoignant ainsi de la porosité entre contextes urbanisés et environnements naturels. (shrink)

L’article discute les conceptions respectives que le philosophe Ernst Cassirer et l’historien de l’art Erwin Panofsky se font de l’espace artistique. L’occasion en est donnée par une discussion lors du Kongress für Ästhetitk und Allgemeine Kunstwissenschaft (Congrès d’esthétique et de science de l’art) organisé à Hambourg en 1933 sur la question de l’espace et du temps artistiques. La perspective, considérée par Panofsky comme une forme symbolique, constitue un bon cas pour saisir les proximités et différences entre l’historien de l’art et (...) le philosophe des formes symboliques. L’espace de la perspective correspond-il à cet espace de l’art que le philosophe définit comme espace de la représentation (Darstellung)? À cet exemple de la perspective, exemple classique quoique souvent évoqué sans grande précision pour comparer les deux théoriciens, l’article en ajoute un autre, inédit, à savoir celui de la théorie des proportions. Peut-on dire que la théorie des proportions qui structure elle aussi la surface de l’image est, comme la perspective, une forme symbolique? La réponse permet de préciser la façon dont Cassirer et Panofsky construisent un lien entre art, représentation et subjectivité. À travers cette recherche des affinités et différences dans la conception de l’art, ce qui se joue en toile de fond, c’est, d’une part, la possibilité et les limites de l’interdisciplinarité et du dialogue fécond entre philosophie et histoire de l’art et, d’autre part, la question de savoir si une commune théorie de l’art était partagée à Hambourg dans ces années, autour de l’Institut Warburg. (shrink)

Dans The Subjection of Women (1869), Mill fait bien plus que prôner l’égalité civique des hommes et des femmes : il entreprend une véritable révolution épistémologique pour déconstruire les représentations naturalisantes du caractère féminin. S’il compare d’abord la condition des femmes à celle des esclaves, c’est pour ensuite l’en distinguer, car la persistance de l’inégalité des sexes est en contradiction avec les principes juridiques des sociétés modernes. Il est donc attentif à la situation singulière du problème de l’assujettissement des femmes (...) : il ne s’agit pas de chercher à faire une « révolution sociale au nom d’un droit abstrait », mais de déraciner les préjugés qui expliquent la permanence archaïque de l’inégalité des sexes. C’est l’occasion d’une réflexion sur la construction de la domination patriarcale comme habitude sociale, par l’influence de l’éducation sur le caractère féminin. (shrink)

Le roi et la reine de France font compte à part : si la séparation du roi et de la reine comme mode habituel de vie de couple princier est bien actée à la fin du Moyen Âge, qu’en était-il au xiiie siècle, c’est-à-dire au moment de l’émergence de l’hôtel réginal? Si la question des institutions et de l’entourage royaux a fait l’objet d’une attention renouvelée ces dernières années elle n’a pas vraiment concerné l’hôtel de la reine. Pourtant la naissance (...) de cet hôtel dans le royaume de France est peut-être à replacer dans un contexte bien plus politique que les historiens ne le laissaient à penser. En effet, l’étude de la personnalité de Marguerite de Provence (1221‑1295) mérite de soulever d’intéressants questionnements en lien avec cette thématique. Il s’agit également d’élaborer une réflexion sur la chronologie de l’apparition institutionnelle de l’hôtel réginal, indépendamment de celui du roi, et de montrer que Marguerite de Provence est probablement la première reine en Occident à en posséder un. (shrink)

The authors present a case study involving truth telling responsibilities in the setting of nonepileptic seizures. Specifically, over the course of several suspected nonepileptic seizures, a patient’s seizures stopped after he received a saline flush meant to precede the administration of anti-seizure medication. The patient and his surrogate believed he had received the medication each time, and the team wondered whether they should disclose the truth. Some worried that disclosure would reinforce the suspected psychogenic behavior, exacerbating the patient’s condition. In (...) this way, the case study presents a twist on the traditional truth telling archetype. While most truth telling cases center on navigating cultural differences or worries about emotional harm, this case presented concerns about medical harm in the form of exacerbating the patient’s condition. The authors describe the complex patient-family-team dynamic that preceded this ethical dilemma, describe the case, analyze the ethical issue, and describe the outcome. (shrink)

Postcolonial science studies entails ostensibly contradictory critical and empirical commitments. Science studies scholars influenced by Bruno Latour and Isabelle Stengers embrace forms of realist, radical empiricism, while postcolonial studies scholars influenced by Jacques Derrida trace the limits of the knowable. This essay takes their common use of the term cosmopolitics as an unexpected point of departure for reconciling Derrida’s program with Stengers’s and Latour’s. I read Derrida’s critique of hospitality and Stengers’s and Latour’s ontological politics as necessary complements for conceiving (...) a care-oriented subalternist cosmopolitics, a process of composing common worlds that remains attentive to the limits of representation. (shrink)

This paper investigates the emotional import of literary devices deployed in fiction. Reflecting on the often-favored approach in the analytic tradition that locates fictional characters, events, and narratives as sources of readers’ emotions, I attempt to broaden the scope of analysis by accounting for how literary devices trigger non-cognitive emotions. I argue that giving more expansive consideration to literary devices by which authors present content facilitates a better understanding of how fiction engages emotion. In doing so, I also explore the (...) somatic dimension of reading fiction. (shrink)

This volume contains the selected discourses of four seventeenth-century philosophers, carefully chosen to illustrate the tenets characteristic of the influential movement known as Cambridge Platonism. Fundamental to their beliefs is the statement most clearly voiced by Benjamin Whichcote, their leader by common consent, that the spiritual is not opposed to the rational, nor Grace to nature. Religion is based on reason, even in the presence of 'mystery'. Free will and Grace are not mutually exclusive. The editor's comprehensive introduction delineates the (...) main principles of the Cambridge Platonists, in the light of their heritage. It compares their attitude to contemporary thought, stressing their mistrust both of institutionalised religion and of the rising tide of materialism. The sermons are reprinted from the original texts and fully annotated with comparisons and references to a wide range of works. The editor also includes a useful list for further reading, biographical notes and a comprehensive index. (shrink)

The philosophical theory of scientific explanation proposed here involves a radically new treatment of causality that accords with the pervasively statistical character of contemporary science. Wesley C. Salmon describes three fundamental conceptions of scientific explanation--the epistemic, modal, and ontic. He argues that the prevailing view is untenable and that the modal conception is scientifically out-dated. Significantly revising aspects of his earlier work, he defends a causal/mechanical theory that is a version of the ontic conception. Professor Salmon's theory furnishes a robust (...) argument for scientific realism akin to the argument that convinced twentieth-century physical scientists of the existence of atoms and molecules. To do justice to such notions as irreducibly statistical laws and statistical explanation, he offers a novel account of physical randomness. The transition from the "reviewed view" of scientific explanation to the causal/mechanical model requires fundamental rethinking of basic explanatory concepts. (shrink)

In ancient China, a revered Taoist sage named Zhuangzi told many parables. In Existential Psychology and the Way of the Tao, a selection of these parables will be featured. Following each parable, an eminent existential psychologist will share a personal and scholarly reflection on the meaning and relevance of the parable for psychotherapy and contemporary life. The major tenets of Zhuangzi's philosophy are featured. Taoist concepts of emptiness, stillness, Wu Wei (i.e. intentional non-intentionality), epistemology, dreams and the nature of reality, (...) character building in the midst of pain, meaning and the centrality of relationships, authenticity, self-care, the freedom that can come from one's willingness to confront death, spiritual freedom, and gradations of therapeutic care are topics highlighted in this book. (shrink)

This reconsideration of Hume’s classic essay “Of Miracles” via the lens of American pragmatist ways of thinking about history and power shifts our attention from Hume’s epistemic concerns about the legitimacy of witnesses and testimony to his distaste for sacred history, his critical stance regarding the social force of revelation, and his disdain for religious authority. To view Hume’s essay both as an articulation of a critical philosophy of history and as an exercise in moral dynamism (social power or, authority, (...) is a result of epistemic transactions), is to intervene in both Hume studies and Contemporary Pragmatism. (shrink)

In this paper I want to do the following things. First I want to show that in the part of the Theaetetus where the relationship between knowledge and perception is examined, the concept of knowledge that is in question is very clearly characterized. We are left in no doubt as to what is to count as knowing. Secondly I want to unravel in some detail the case that Socrates puts on Protagoras’ behalf where he draws on what Protagoras actually wrote (...) (151 E-152C); as opposed to what he may have taught secretly to his pupils (152C-160D). Thirdly I wish to argue that if we let the dialogue speak for itself, it is manifest that this case put up on Protagoras’ behalf at 151 E-152C is not overthrown; it is not even shaken. (shrink)

What is post-truth? -- Science denial as a road map for understanding post-truth -- The roots of cognitive bias -- The decline of traditional media -- The rise of social media and the problem of fake news -- Did post-modernism lead to post-truth? -- Fighting post-truth.

Talent and Education was first published in 1960. Minnesota Archive Editions uses digital technology to make long-unavailable books once again accessible, and are published unaltered from the original University of Minnesota Press editions.The problem of identification, development, and utilization of talented young people is a matter of prime concern to all who are interested in the welfare of the individual and the future of the nation. This book, constituting a progress report on research related to the problem, will be of (...) particular value to educators, psychologists, social workers, community leaders, and others who are engaged in the effort to make the most of our human resources.The volume contains chapters by a number of contributors drawn from various fields in elementary, secondary, and higher education. The contributors include John E. Anderson, Robert H. Beck, Florence N. Brumbaugh, Walter W. Cook, Willis E. Dugan, Dale B. Harris, Arthur J. Lewis, Catherine Cox Miles, Mary Pilch, Maynard C. Reynolds, Anne Roe, Merrill F. Roff, Paul C. Rosenbloom, Audrey Shechtman, and E. Paul Torrance. Orville L. Freeman, governor of Minnesota, writes an indtroduction.Among the topics discussed are the nature and scientific measurement of talent, the effects of life experiences on the development of talent, the enrichment of school curricula, special grouping and acceleration in the schools, psychological aspects of some of the problems, and Russian methods of dealing with individual differences. The volume is based on papers from an Institute on Exceptional Children held at the University of Minnesota. (shrink)

The widespread use of stimulants among healthy individuals to improve cognition has received growing attention; however, public attitudes toward this practice are not well understood. We determined the effect of framing metaphors and context of use on public opinion toward cognitive enhancement. We recruited 3,727 participants from the United States to complete three surveys using Amazon’s Mechanical Turk between April and July 2017. Participants read vignettes describing an individual using cognitive enhancement, varying framing metaphors (fuel versus steroid), and context of (...) use (athletes versus students versus employees). The main outcome measure was the difference in respondent-assigned level of acceptability of the use of cognitive enhancement by others and by themselves between the contrasting vignettes. Participants were more likely to support the use of cognitive enhancement by others than by themselves and more when the use of enhancement by others was framed with a fuel metaphor than with a steroid metaphor. Metaphoric framing did not affect participants’ attitudes toward their own use. Participants supported the use of enhancement by employees more than by students or athletes. These results are discussed in relation to existing ethical and policy literature. (shrink)

In our papers on the rationality of magic, we distinghuished, for purposes of analysis, three levels of rationality. First and lowest (rationalitYl) the goal directed action of an agent with given aims and circumstances, where among his circumstances we included his knowledge and opinions. On this level the magician's treatment of illness by incantation is as rational as any traditional doctor's blood-letting or any modern one's use of anti-biotics. At the second level (rationalitY2) we add the element of rational thinking (...) or thinking which obeys some set of explicit rules, a level which is not found in magic in general, though it is sometimes given to specific details of magical thinking within the magical thought-system. It was the late Sir Edward E. Evans-Pritchard who observed that when considering magic in detail the magician may be as consistent or critical as anyone else; but when considering magic in general, or any system of thought in general, the magician could not be critical or even comprehend the criticism. Evans-Pritchard went even further: he was sceptical as to whether it could be done in a truly consistent manner: one cannot be critical of one's own system, he thought. On this level (rationalitY2) of discussion we have explained (earlier) why we prefer to wed Evans Pritchard's view of the magician's capacity for piece-meal rationality to Sir James Frazer's view that magic in general is pseudo-rational because it lacks standards of rational thinking. (shrink)

The eight essays and three responses collected in Rethinking Borders were commissioned from an exciting range of leading younger writers, artists and intellectuals whose work has raised significant questions about the border cultures in ...

In this paper I want to do the following things. First I want to show that in the part of the Theaetetus where the relationship between knowledge and perception is examined, the concept of knowledge that is in question is very clearly characterized. We are left in no doubt as to what is to count as knowing. Secondly I want to unravel in some detail the case that Socrates puts on Protagoras’ behalf where he draws on what Protagoras actually wrote (...) ; as opposed to what he may have taught secretly to his pupils. Thirdly I wish to argue that if we let the dialogue speak for itself, it is manifest that this case put up on Protagoras’ behalf at 151 E-152C is not overthrown; it is not even shaken.In that part of the dialogue where the question is under examination whether or not knowledge and perception are the same, Socrates uses an idealized concept of knowledge. That is, he restricts the use of the word by setting down what he will consider to be the essential characteristics of knowledge, the sufficient and necessary conditions of its being instantiated. An excellent piece of philosophical procedure. (shrink)

A critical survey of the main philosophical theories about events and event talk, organized in three main sections: (i) Events and Other Categories (Events vs. Objects; Events vs. Facts; Events vs. Properties; Events vs. Times); (ii) Types of Events (Activities, Accomplishments, Achievements, and States; Static and Dynamic Events; Actions and Bodily Movements; Mental and Physical Events; Negative Events); (iii) Existence, Identity, and Indeterminacy.

Just as humans can draw conclusions responsibly or irresponsibly, so too can computers. Machine learning systems that have been trained on data sets that include irresponsible judgments are likely to yield irresponsible predictions as outputs. In this paper I focus on a particular kind of inference a computer system might make: identification of the intentions with which a person acted on the basis of photographic evidence. Such inferences are liable to be morally objectionable, because of a way in which they (...) are presumptuous. After elaborating this moral concern, I explore the possibility that carefully procuring the training data for image recognition systems could ensure that the systems avoid the problem. The lesson of this paper extends beyond just the particular case of image recognition systems and the challenge of responsibly identifying a person’s intentions. Reflection on this particular case demonstrates the importance (as well as the difficulty) of evaluating machine learning systems and their training data from the standpoint of moral considerations that are not encompassed by ordinary assessments of predictive accuracy. (shrink)

It is my conviction that much of the criticism of John Rawls’A Theory of Justicemisses its mark precisely because of a failure to appreciate the distinctive methodological structure of this work. I have three types of criticisms specifically in mind. First, the critic whose ultimate weapon is the counterexample. Secondly, the critic who focuses on one aspect of Rawls’ project without taking into account the whole theory. And thirdly, the critic who attempts to assess the theory absolutely rather than as (...) one member of a set of welldefined alternatives. In this paper I hope to exhibit why these kinds of criticisms miss the mark, and I propose to do this indirectly by focusing on Rawls’ conception of philosophical method. Once this is exhibited, the relevance and irrelevance of certain kinds of criticisms becomes obvious. In my attempt to explicate Rawls’ conception of method, I will begin with his early methodological papers as providing the context within which the methodological structure ofA Theory of justiceshould be viewed. (shrink)

What proper role should considerations of risk, particularly to research subjects, play when it comes to conducting research on human enhancement in the military context? We introduce the currently visible military enhancement techniques (1) and the standard discussion of risk for these (2), in particular what we refer to as the ‘Assumption’, which states that the demands for risk-avoidance are higher for enhancement than for therapy. We challenge the Assumption through the introduction of three categories of enhancements (3): therapeutic, preventive, (...) and pure enhancements. This demands a revision of the Assumption (4), alongside which we propose some further general principles bearing on how to balance risks and benefits in the context of military enhancement research. We identify a particular type of therapeutic enhancements as providing a more responsible path to human trials of the relevant interventions than pure enhancement applications. Finally, we discuss some possible objections to our line of thought (5). While acknowledging their potential insights, we ultimately find them to be unpersuasive, at least provided that our proposal is understood as fully non-coercive towards the candidates for such therapeutic enhancement trials. (shrink)

The flowering of creative and speculative philosophy that emerged in modern Europe--particularly in Germany--is a thrilling adventure story as well as an essential chapter in the history of philosophy. In this integrative narrative, Solomon provides an accessible introduction to the major authors and movements of modern European philosophy, including the Enlightenment and Romanticism, Rousseau, German Idealism, Kant, Fichte, Schelling and the Romantics, Hegel, Schopenhauer, Kierkegaard, Feuerbach, Max Brentano, Meinong, Frege, Dilthey, Bergson, Nietzsche, Husserl, Freud, Wittgenstein, Heidegger, hermeneutics, Sartre, Postmodernism, Structuralism, (...) Foucault, and Derrida. (shrink)